Emotional indicators and human milk feeding modalities in mothers of preterm infants during hospitalization
DOI:
https://doi.org/10.36097/rsan.v1i67.4357Keywords:
Breastfeeding, immunoglobulin A, maternal depression, neonatal intensive care unit, prematurityAbstract
Hospitalization of a preterm infant in a neonatal intensive care unit may affect maternal emotional well-being and influence opportunities for maternal participation in feeding. This study aimed to assess indicators of anxiety and depression in mothers of preterm infants at two points during hospitalization, analyze their patterns according to human milk feeding modalities, and describe the macronutrient and immunoglobulin A composition of the mother’s own human milk (LHC). A quantitative, observational, longitudinal study was conducted with 55 mothers of infants born at less than 32 weeks of gestation and weighing less than 1,500 g. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale at the beginning of hospitalization and during the week prior to discharge. In a subsample of 20 mothers, protein, triglyceride, lactose, and immunoglobulin A concentrations were analyzed between postpartum days 25 and 30. Anxiety and depression scores decreased significantly between the two assessment points. Analysis by human milk feeding modality showed differences in anxiety and different trajectories of depression across groups. Milk samples showed variability in their composition and a mean immunoglobulin A concentration of 224.25 mg/dL. The findings indicate a favorable evolution of maternal emotional indicators during hospitalization, although they do not allow identification of the factors responsible for this change. The results highlight the importance of assessing maternal emotional well-being and supporting feeding with the mother’s own milk throughout hospitalization.
Downloads
References
Adama, E. A., Adua, E., Bayes, S., & Mörelius, E. (2022). Support needs of parents in neonatal intensive care unit: An integrative review. Journal of Clinical Nursing, 31(5–6), 532–547. https://doi.org/10.1111/jocn.15972
Gates, A., Marin, T., De Leo, G., & Waller, J. L. (2021). Nutrient composition of preterm mother’s milk and factors that influence nutrient content. The American Journal of Clinical Nutrition, 114(5), 1719–1728. https://doi.org/10.1093/ajcn/nqab226
Gercovich, N., Gercovich, D., Torrente, F., López, P., Bortolato, D., Margiolakis, P., Morgenfeld, M., Rosell, L., Paoloski, G., & Pollola, J. (2008). Adaptation and validation of the Hospital Anxiety and Depression Scale (HADS) to a cohort of patients in Buenos Aires, Argentina. Journal of Clinical Oncology, 26(15_suppl), 20616. https://doi.org/10.1200/jco.2008.26.15_suppl.20616
Gidrewicz, D. A., & Fenton, T. R. (2014). A systematic review and meta-analysis of the nutrient content of preterm and term breast milk. BMC Pediatrics, 14, 216. https://doi.org/10.1186/1471-2431-14-216
Hanson, L. Å. (1998). Breastfeeding provides passive and likely long-lasting active immunity. Annals of Allergy, Asthma & Immunology, 81(6), 523–533. https://doi.org/10.1016/S1081-1206(10)62704-4
Hurley, W. L., & Theil, P. K. (2011). Perspectives on immunoglobulins in colostrum and milk. Nutrients, 3(4), 442–474. https://doi.org/10.3390/nu3040442
McLeish, J., Aloysius, A., Gale, C., Quigley, M. A., Kurinczuk, J. J., & Alderdice, F. (2024). What supports mothers of very preterm babies to start and continue breast milk feeding in neonatal units? A qualitative COM-B analysis of mothers’ experiences. BMC Pregnancy and Childbirth, 24, Article 725. https://doi.org/10.1186/s12884-024-06910-4
Meier, P. P., Johnson, T. J., Patel, A. L., & Rossman, B. (2017). Evidence-based methods that promote human milk feeding of preterm infants: An expert review. Clinics in Perinatology, 44(1), 1–22. https://doi.org/10.1016/j.clp.2016.11.005
Mimouni, F. B., Lubetzky, R., Yochpaz, S., & Mandel, D. (2017). Preterm human milk macronutrient and energy composition: A systematic review and meta-analysis. Clinics in Perinatology, 44(1), 165–172. https://doi.org/10.1016/j.clp.2016.11.010
Nguyen, C. T. T., Sandhi, A., Lee, G. T., Nguyen, L. T. K., & Kuo, S.-Y. (2023). Prevalence of and factors associated with postnatal depression and anxiety among parents of preterm infants: A systematic review and meta-analysis. Journal of Affective Disorders, 322, 235–248. https://doi.org/10.1016/j.jad.2022.11.015
Ohuma, E. O., Moller, A.-B., Bradley, E., Chakwera, S., Hussain-Alkhateeb, L., Lewin, A., Okwaraji, Y. B., Mahanani, W. R., Johansson, E. W., Lavin, T., Estevez Fernandez, D., Gatica-Domínguez, G., de Costa, A., Cresswell, J. A., Krasevec, J., Lawn, J. E., & Blencowe, H. (2023). National, regional, and global estimates of preterm birth in 2020, with trends from 2010: A systematic analysis. The Lancet, 402(10409), 1261–1271. https://doi.org/10.1016/S0140-6736(23)00878-4
Pavlyshyn, H., & Sarapuk, I. (2025). What influences maternal stress in the NICU among mothers of preterm infants? Frontiers in Pediatrics, 13, 1592768. https://doi.org/10.3389/fped.2025.1592768
Rosen-Carole, C. B., Greenman, S., Wang, H., Sonawane, S., Misra, R., O’Connor, T., Järvinen, K., D’Angio, C., & Young, B. E. (2024). Association between maternal stress and premature milk cortisol, milk IgA, and infant health: A cohort study. Frontiers in Nutrition, 11, 1270523. https://doi.org/10.3389/fnut.2024.1270523
Shetty, A. P., Halemani, K., Issac, A., Thimmappa, L., Dhiraaj, S., Radha, K., Mishra, P., & Upadhyaya, V. D. (2024). Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: A systematic review and meta-analysis. Clinical and Experimental Pediatrics, 67(2), 104–115. https://doi.org/10.3345/cep.2023.00486
Surmeli Onay, O., Sarilar, T. D., Taskiran Tepe, H., Ozen, H., & Tekin, N. (2021). The relationship of breastfeeding patterns in the neonatal intensive care unit to maternal symptoms of anxiety and depression. Breastfeeding Medicine, 16(3), 251–257. https://doi.org/10.1089/bfm.2020.0223
Torrecilla, N. M., Contreras-Zapata, D. I., Waldheim-Arizu, J., & Valdez, S. R. (2025). Indicadores psicológicos y hormonales de estrés (cortisol y prolactina sérica) en madres de prematuros internados en una Unidad de Cuidados Intensivos Neonatales (UCIN). Horizonte Médico, 25(2), e3044. https://doi.org/10.24265/horizmed.2025.v25n2.05
Torrecilla, N. M., González, F., & Waldheim Arizu, J. (2020). Percepción de eficacia materna y autoestima materna luego de una internación en una unidad de cuidados intensivos neonatal. Investigaciones en Psicología, 24(2), 43–49. https://doi.org/10.32824/investigpsicol.a24n2a25
Torrecilla, N. M., Waldheim-Arizu, J., & Contreras-Zapata, D. I. (2023). Ansiedad, depresión e interacciones vinculares en madres de prematuros durante el período de internación en una unidad de cuidados intensivos neonatales (UCIN) y prealta de sus hijos. Revista Científica Multidisciplinaria Arbitrada YACHASUN, 7(12), 111–127. https://doi.org/10.46296/yc.v7i12.0277
Wang, L. L., Ma, J. J., Meng, H. H., & Zhou, J. (2021). Mothers’ experiences of neonatal intensive care: A systematic review and implications for clinical practice. World Journal of Clinical Cases, 9(24), 7062–7072. https://doi.org/10.12998/wjcc.v9.i24.7062
Zigmond, A. S., & Snaith, R. P. (1983). The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica, 67(6), 361–370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Norma Mariana Torrecilla, Jennifer Waldheim Arizu, Denise Ilcen Contreras Zapata, Susana Ruth Valdez

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.









